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Dassault Systèmes executives kick off the 8th International Symposium on the Living Heart and Virtual Twin for Humans with presentations on the current state of the virtual human twin, Dassault Systèmes vision for Life Sciences & Healthcare and an introduction to the LIU Center of Excellence for Life Sciences.
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Danny Bluestein, head of the Biofluids Research Group at Stony Brook University, discusses the use of Fluid Structure Interaction and computational modeling and simulation for the optimization of prosthetic devices and procedures for treating cardiovascular diseases, and the mechanobiology of thrombosis across the scales.
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Patrick Johnson, Head of Research at Dassault Systèmes, shares his view on what the virtual twin means in its broadest sense and how these models coupled with modeling, simulation, big data, and collaboration can help healthcare move forward and address the challenges of today.
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Symon Reza, a Research Assistant in the Biofluids Research Group, presents his work to understand the mechanism of developing Cardiac Conduction Abnormality following transcatheter aortic valve replacement (TAVR) procedures using a beating, dynamic electro-mechanical virtual heart model.
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Alireza Heidari, Research Associate at McGill University, discusses the use of Computational Fluid Dynamics and Fluid Structure Interaction methods to accurately predict the rupture of patient-specific aortic aneurysms.
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Brandon Kovarovic, presents his work to optimize a polymeric TAVR with a robust finite element testing regimen for reducing stresses-enhancing performance and durability. The Living Heart model was utilized for the testing of the device stent fatigue under physiological conditions.
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Salwa Anam of Stony Brook University presents an overview of her work to leverage the Living Heart Left Heart Model to analyze clinical complications associated with the use of current TAVR devices in BAV patients. Addressing the anatomical features of BAV, Salwa and team developed a dedicated optimized design of a BAV-specific novel TAVR device with eccentric orifice for improved performance.
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Nuno Rebelo presents a hypothetical finite element model of a lung that includes the lung tissue, the pleura and airways. The model is based on a coupled pore pressure and solid mechanics formulation, with the solid part being a very compressible hyperelastic material. The model 'breathing' is demonstrated either as subjected to active ventilation or as a passive iron lung.
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Nicolas Gallo, Assistant Professor at Long Island University, announces the kick off of the Living Liver Project, establishing the dire need for a virtual twin of the liver to bring the most promising drugs to market.
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Steve Levine, Founder & Executive Director of the Living Heart Project and Virtual Human Modeling Senior Director at Dassault Systèmes, takes listeners back to the origins of the Living Heart Project with a brief history of the project and also provides a glimpse of the current state of the Living Heart model and member contributions.
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Dr. David Hoganson, Pediatric Cardiologist at Boston Children’s Hospital, discusses the transformative impact of using virtual patient twin simulations to improve clinical outcomes in pediatric cardiac surgery. Working with a team of biomedical engineers led by Dr. Peter Hammer from Harvard Medical School, the team takes on the most challenging cardiovascular reconstructive surgeries, often on newborn children to plan the optimum surgical plan in advance of entering the OR. Converting standard 2D imaging into patient-specific 3D functional models, surgeons collaborate with the engineers using the virtual patient to test surgical options, reducing risks, saving OR time and saving lives. Dr Hoganson showcases breakthrough uses of the powerful computational modeling and simulation tools on the 3DEXPERIENCE platform, to obtain engineering precision in designing patient specific tissue implants that take the guesswork out of these surgeries and transforming the entire patient experience.
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Nicolas Gazéres, Virtual Twin of Human Technology Director at Dassault Systèmes, shares his and his team's work to enhance the clinical staff meeting experience through the development of an app for pre-surgical planning. Surgical situations can be anticipated thanks to a 360 degree view of the virtual twin of the patient's brain. The app also promotes collaboration and a common understanding of the electrophysiological structure of the seizure, thereby facilitating more informed decision making.
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Ed Margerrison, Director of the Office of Science and Engineering at the US Food and Drug Administration, discusses the Importance of Regulatory Science Tools for increasing innovation and product development as well as the FDA's involvement in the Living Heart Project.
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Steve Levine, Founder & Executive Director of the Living Heart Project and Virtual Human Modeling Senior Director at Dassault Systèmes, gives an overview of the US FDA joint project, the ENRICHMENT in silico Clinical Trial, and explains how virtual patient populations can revolutionize clinical trials and regulatory submissions by providing a faster, richer and safer review process.
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Afrah Shafquat, Medidata AI Synthetic Data Scientist, presents her work on the use of simulants in a virtual patient framework.
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Jean-Philippe Laguerre discusses how Dassault Systèmes is working hand-in-hand with leading academic institutions to help build the workforce of the future through Centers of Excellence.
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Abhishek Bali, 3DEXPERIENCE WORKS Startup Ecosystem Director at Dassault Systèmes, gives an overview of the 3DEXPERIENCE Lab, an open innovation laboratory founded by Dassault Systèmes to help startups who are developing disruptive technologies that will have a positive impact on society and the planet.
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Steve Levine, Founder & Executive Director of the Living Heart Project and Virtual Human Modeling Senior Director at Dassault Systèmes, provides an inspiring conclusion to the 8th International Symposium on the Living Heart and Virtual Twin of Human and shares his thoughts on the future of the virtual human twin.
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