June 10, 2025
2:00 PM - 3:00 PM (your local time)
Join our webinar to explore the discovery of a novel inhibitory site on the mGlu7 receptor using GOLD and BIOVIA Discovery Studio.
The metabotropic glutamate 7 (mGlu7) receptor plays a crucial role in synaptic regulation, making it a promising target for therapeutic interventions in conditions such as post-traumatic stress disorder, epilepsy, and anxiety. XAP044 is a negative allosteric modulator of mGlu7 that prevents receptor activation by stabilizing the Venus flytrap domain in an open state. We combined computational modeling with BIOVIA Discovery Studio, docking simulations with GOLD, and mutagenesis experiments, and uncovered a unique mechanism of action of XAP044.
Whether you are a medicinal chemist, computational biologist, or neuroscientist, don’t miss the opportunity to learn how integrating computational and experimental approaches can accelerate breakthroughs in drug discovery.
Webinar highlights:
Register now to reserve your space!