7th International Symposium: Virtual Twin of Human & Living Heart

Day 1 Opening Remarks & Plenary Session

A look at the Dassault Systèmes journey toward the virtual twin experience of the human body followed by clinical perspectives and a Living Heart Project technical and community update.

• Welcome and Introduction- Steve Levine, Dassault Systèmes
• The Dawn of the Virtual Human Twin - Claire Biot & Patrick Johnson, Dassault Systèmes 
• View from the Field – 3D in Clinical Practice
• -3D for Virtual Surgical Planning - Silvina Zabala Travers, MD, Pereira Rossell Hospital
• -3D for Simulating Surgical Outcomes - David Hoganson, MD, Boston Children’s Hospital
• -Panel: Adoption of Virtual Twins in Clinical Environment
• Making Healthcare Smart - Sensor Cloud to Transform Biomarkers Into Evidence - Arnaub Chatterjee, Dassault Systèmes 
• Living Heart & Virtual Human Twin Community Update - Steve Levine, Dassault Systèmes

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Fireside Chat: Transformations in Regulatory Science at the FDA

A discussion with Tina Morrison, U.S. Food and Drug Administration and Daniel Matlis, Axendia, on transformations in regulatory science at the FDA.

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Virtual Twins for Pharmaceutical Applications

Notable scientific studies using the virtual twin of human in pharmaceutical applications.

• Sex Differences in Drug-induced Arrhythmogenesis -  Mathias Peirlinck, Delft University of Technology
• Personalized Modeling of Alzheimer's Disease Using AI - Ellen Kuhl, Stanford University 

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Taking Virtual Twins into New Domains

Applications beyond cardiovascular.

• Brain Shape Changes Associated With Cerebral Atrophy in Healthy Aging and Alzheimer’s  Disease - Johannes Weickenmeier, Stevens Institute of Technology
• FDA Enrichment in silico Clinical Trial - Steve Levine, Dassault Systèmes with Brent Craven & Kenneth Aycock, U.S. Food & Drug Administration

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Pursuits of Excellence Breakout: Virtual Patients and Pandemic Response / Preparedness

A presentation on Computational Epidemiology Modeling COVID-19 Progression by Ellen Kuhl, Stanford University, followed by a discussion led by Steve Levine on the use of virtual patients in pandemic response and preparedness.
 

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Pursuits of Excellence Breakout: AI & ML with Virtual Human Modeling for Rational Digital Health

An exploration of the use of AI and Machine Learning for rational digital health.

• Detection and the Geometrical Information Extraction of Endocardial Scar Tissue in Left Ventricular Using CT Modalities - Yashbir Singh, Mayo Clinic
• A Machine Learning Platform for Prediction of MitraClip Intervention - Yaghoub Dabiri, 3DT Holdings & Wolfgang Gentzsch, The UberCloud 
• Using ML Trained with the Living Heart Simulations to Create a Representative Patient Population - Zhenxiang Jiang, Dassault Systèmes

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Pursuits of Excellence Breakout: Living Heart Model Applications

A deep dive into cardiovascular modeling and simulation. 

• Interplay Between Cardiac Microtissue Structure and Function - An in silico Approach - Milica Nikolic, Eindhoven University of Technology
• Living Heart Mesh Morphing for Generating Subject-specific Models - Jonathan Weissmann, Tel Aviv University
• Uncovering the Effects of Structural Intervention on the Human Tricuspid Valve Using Predictive Models - Mrudang Mathur, The University of Texas at Austin

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Virtual Twin for Accelerated Aging Studies & Day 1 Closing Remarks

• Characterization of Exercise-Induced Myocardium Growth Using Finite Element Modeling and Bayesian Optimization - Yiling Fan, Massachusetts Institute of Technology
• An Initial Experience of Constrained Mixture Based-cardiac Growth and Remodelling - Hao Gao, University of Glasgow
• Closing Remarks - Steve Levine, Dassault Systèmes

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Day 2 Opening Remarks & Plenary Session

• Day 1 Recap & Day 2 Outlook - Steve Levine, Dassault Systèmes
• Importance of Regulatory Science Tools - Ed Margerrison, U.S. Food & Drug Administration
• FEops HEARTguide, Combining Digital Twins with AI for Unprecedented Structural Heart Disease Management - Matthieu De Beule, FEops
• Patient-Specific Analysis of Ascending Thoracic Aortic Aneurysm with the Living Heart  Human Model - Salvatore Pasta, University of Palermo
• Oncology Tumor Assessment - Meriem Ben Abdallah-Bernstein, Dassault Systèmes
• Towards a COVID-19 Patient-specific Virtual Lung - Daniel Hurtado, Pontificia Universidad Católica de Chile  
• Panel: Virtual Twin from Molecules to Bodies - Reza Sadeghi, Steve Levine & Victor Oancea, Dassault Systèmes

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Building the Virtual Human Twin Breakout: Living Brain & Living Lung Projects Planning

A discussion led by Steve Levine, Dassault Systèmes to advance the Living Brain and Living Lung Projects.

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Building the Virtual Human Twin Breakout: Accelerating the Use of Virtual Patients in the Regulatory Framework

A presentation of methodologies for digital biomarkers and synthetic patients for more informed clinical trials by Arnaub Chatterjee, Ruthie Davi & Jacob Aptekar, Medidata Solutions
 

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Building the Virtual Human Twin Breakout: The Workforce of the Future

Jean-Philippe Laguerre, Dassault Systèmes, spotlights the virtual twin of human in education with presentations from Natacha De Paola, Illinois Institute of Technology & Nicolas Gallo, Long Island University.  

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Building the Virtual Human Twin Breakout: Living Heart

Living Heart Project Members' Meeting, hosted by Tom Battisti & Jiang Yao, Dassault Systèmes

Please note, this link directs to the LHP Members Community which is only open to current Members of the Living Heart Project.

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Innovation Centers

Laurent Coste, Dassault Systèmes, explains how the 3DEXPERIENCE Lab empowers disruptive startups with an example Jose Wong, Dynocardia. 

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Virtual Twin Application Showcase & Closing Remarks

Latest breakthroughs in virtual human simulation.

• Use of the Living Heart as an Engine to Generate a Virtual Patient Cohort for an in silico  Trial of a Medical Device: Application to Left Atrial Appendage Occlusion - Steve Kreuzer & Paul Briant, Exponent
• Modelling Strategies for Medical Devices in Living Heart - Part I - Nils Götzen , 4RealSim Services BV
• Modelling Strategies for Medical Devices in Living Heart - Part II - Karthik Thalappully. Dassault Systèmes
• Learning Atrial Fiber Orientations from Intracardiac Maps Using Physics-informed Neural Networks - Francisco Sahli Costabal, Pontificia Universidad Católica de Chile
• Fluid-Structure Interaction Simulations for Bio-Prosthetic Heart Valves: Challenges, Solutions and Applications - Harkamaljot Kandail, CAPVIDIA
• Hemodynamics of the Living Heart with an Left Ventricular Assist Device - Elena Ovsyannikova, TESIS, Ltd.
• Risk Assessment of Cardiac Conduction Abnormality Associated with TAVR Using the Living Heart Human Model - Symon Reza, Stony Brook University
• Modeling and Simulation of Patient-specific Aortic Root with Calcific Aortic Valve Disease (CAVD) Using the 3DEXPERIENCE Left Heart Model - Salwa Anam, Stony Brook University
• Closing Remarks - Steve Levine, Dassault Systèmes

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