6th Annual Living Heart Symposium Replay

Day 1 Plenary Session, Part 1

A look at the Dassault Systèmes journey toward the virtual twin experience of the human body followed by a Living Heart Project technical and community update and notable scientific studies in human modeling

• Welcome and Opening Remarks - Steve Levine, Dassault Systèmes
• A Journey Towards the Virtual Twin Experience of the Human Body - Claire Biot & Patrick Johnson, Dassault Systèmes 
• The Living Heart Project - Steven Levine, Dassault Systèmes
• Scientific Breakthroughs in Human Modeling:
  • Living Heart:  Mathias Peirlinck, Stanford University

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Day 1 Plenary Session, Part 2

Notable scientific studies in human modeling

• Scientific Breakthroughs in Human Modeling:
  • Living Lung: Daniel Hurtado, Pontificia Universidad Católica de Chile, Mona Eskandari, University of California Riverside 
  • Living Brain: Nicolas Gazeres, Dassault Systèmes

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Student Showcase

Brief overviews of student research, offering a glimpse into the future of healthcare, hosted by Suyog Bhosale, Dassault Systèmes  

• Effects of Dispersed Myofibre Architecture on Ventricular Pump Function, Debao Guan, University of Glasgow
• Virtual Human Modelling and Simulation to Investigate Genetic Heart Diseases,    Francesca Margara, University of Oxford
• Investigating the Soft-tissue Socket Interaction During Gait using FEA, Theodoros Marinopoulos, Loughborough University
• FE Study of Heterotopic Ossification Formation on a Cervical Spine with Artificial Disc, Srikanth Srinivasan, Dilip Kumar S, Shruthi Ramachandran, S K Pugazhenthi, Deepak S, Senthil Kumar M, Balaji H, Vellore Institute of Technology- Chennai
• Biomechanical Simulations of Resuscitation, Gunda Sachin, Indian Institute of Technology (IIT) Hyderabad

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FDA ENRICHMENT Project

Overview and Status Update on the FDA In silico Clinical Trial Project, Brent Craven, US Food and Drug Administration & Steven Levine, Dassault Systèmes

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Pursuits of Excellence - Accelerating Use of in Silico Clinical Trials

LH Symposium Breakout:  Accelerating the Use of in Silico Clinical Trials, hosted by Najib Abboud, Thornton Tomasetti  

• Industry Perspectives on the Use of Computational Modeling & Simulation, Randy Scheistl, Boston Scientific
• The Harvi Cardiovascular Simulation: Exploration of Surrogate Endpoints for an In silico Trial of MR Therapy, Daniel Burkhoff MD, Cardiovascular Research Foundation
• What Slows the Adoption of In-silico Clinical Trials? (Panel) Najib Abboud, Thornton Tomasetti (Moderator); Randy Scheistl, Boston Scientific;  Daniel Burkhoff MD, Cardiovascular Research Foundation;  Alison Marsden, Stanford University; Dorothy Abel, Syntactx; Ashley Peterson, Thornton Tomasetti, Partho Sengupta, West Virginia University

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Pursuits of Excellence - Building Patient-Specific Models

LH Symposium Breakout:  Building Patient-Specific Models, hosted by Tom Battisti, Dassault Systèmes

• Leveraging Machine Learning-based AI to Quickly Build Patient-Specific Living Heart Models, Kerim Genc, Synopsys  &  Paul Segars, Duke University
• Pediatric Heart Modeling in a Clinical Environment, Noah Schulz, Boston Children’s Hospital
• Patient/Population-Based Anatomical Modeling and Simulation, Ryan Benyshek  &  Ashley Stroh, Dassault Systèmes
• Patient-Specific Simulation Parameter Tuning, Jiang Yao, Dassault Systèmes

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Pursuits of Excellence - Case Studies & Benefits of HPC on Cloud

LH Symposium Breakout:  Case Studies and Benefits of High-Performance Computing for Human Simulations In The Cloud, Hosted by Wolfgang Gentzsch, The UberCloud

• High-performance Cloud computing for human simulations, digital twins, big data analytics, and AI,  Wolfgang Gentzch, The UberCloud
• Multi-scale Modeling of Drug-induced Arrhythmias, Francisco Sahli, Pontificia Universidad Católica de Chile
• Simulation of a Personalized Left Atrial Appendage Occluder Device with the Living Heart Model in the Cloud, Philipp Hempel, Admedes GmbH
• Numerical Simulations in Cardiovascular Device Development and the Significance of Cloud Computing, Deepanshu Sodhani, Enmodes
• HPC Cloud Simulation of Direct Current Brain Stimulation in Schizophrenia, Karl D’Souza, Dassault Systèmes 

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Pursuits of Excellence – Machine Learning & Other Reduced Order Models

LH Symposium Breakout:  Machine Learning and Other Reduced Order Models, hosted by Steve Levine, Dassault Systèmes

• AI/ML in Life Sciences, Jing Bi, Dassault Systèmes
• LHP Models to Train Machine Learning Model for Clinical Use, Julius Guccione, University of California San Francisco
• Modelica Models for Cardiovascular System Modeling, Filip Ježek, University of Michigan

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Clinical Applications of Virtual Organs & Closing Remarks

Clinical Applications of Virtual Organs & Closing Remarks, hosted by Steve Levine, Dassault Systèmes

• Utilization of 3D Models and Computational Simulations to Improve Operative Planning for Pediatric Cardiac Surgery, David Hoganson, MD, Boston Children’s Hospital
• Patient-Specific Modeling of Heart Failure for COVID-19 Cases, Cristina Pop, MD & Alireza Heidari, McGill University
• FE Solver Based Subject-specific Musculoskeletal Model for Analyzing Lower Extremity Biomechanics, Shihao Li, University of Tokyo

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Day 2 Plenary Session

Day 1 recap and goals for the day, followed up by the latest innovations in cardiovascular modeling and simulation

• Day 1 Recap & Day 2 Outlook, Steven Levine, Dassault Systèmes
• Replicating and Validating In Vivo Conditions to Simulate Leadless Pacemaker Motion in a Virtual Porcine Heart, Kevin Sack, Medtronic
• Left Ventricular Biomechanics in Aortic Stenosis: Application of the Living Heart Human Model, Yunjie Wang, Thornton Tomasetti
• Precision Structural Heart Interventions, Matthieu De Beule, FEops
• Living Human Heart Project Mitral Valve Fluid-Structure Interaction Simulation, Tomasz Luniewski, CAPVIDIA

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Building the Virtual Human Twin - Living Brain

LH Symposium Breakout:  Building the Human Twin - Living Brain, hosted by Steve Levine, Dassault Systèmes

• Brain Virtual Twin Generation Workflow for Epilepsy Surgery, Louise Moreau, Benoit Sarthou & Antoine Guillemain, Dassault Systèmes
• Discussion Steve Levine, Dassault Systèmes (moderator)

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Building the Virtual Human Twin - Living Heart

LH Symposium Breakout:  Building the Human Twin Session - Living Heart, hosted by Tom Battisti, Dassault Systèmes
Please note, this link directs to the LHP Members Community which is only open to current Members of the Living Heart Project.

• Technology and Model Update, Tom Battisti, Jiang Yao & Ashley Stroh, Dassault Systèmes
• Mitral Valve Special Interest Group, Steve Kreuzer, Exponent, Inc.
• Project Checkup, Tom Battisti, Dassault Systèmes

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Building the Virtual Human Twin - Living Lung

LH Symposium Breakout:  Building the Human Twin Session - Living Lung, hosted by Stuart Wright, Dassault Systèmes

• Current Pulmonary Modeling and Simulation Applications Daniel Hurtado, Pontificia Universidad Católica de Chile, Mona Eskandari, University of California Riverside, Quentin Rouanet, Dassault Systèmes
• Discussion,  Stuart Wright, Dassault Systèmes (moderator)

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Application Showcase

Latest breakthroughs in virtual human simulations

• Numerical Analysis of Healthy, Diseased, and Prosthetic Aortic Valve within the LHHM, Adi Morany, Tel Aviv University
• A Multi-Physics Simulation Framework Using Four-Chamber Cardiac Models, Adarsh Krishnamurthy, Iowa State University
• Improving Patient Outcomes with an AI-driven Automation for Scan-to-print, Andy Kalambi, Rize, Inc. Subject-Specific Computational Models of the Human Tricuspid Valve, Manuel Rausch & Mrudang Mathur, University of Texas, Austin

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Innovation Centers, Future Direction & Closing Remarks

An overview of the 3DExperience Lab and Workforce of the Future -  Dassault Systèmes approach to foster entrepreneurship and strengthen society´s future of creation

• ViTrack™, the First Standalone Continuous Non-invasive Blood Pressure Monitor,  Mohan Thanikachalam, Dynocardia
• Developing and Validating Personalized Digital Human Brain Models for Neuro-psychiatric Disorders, Laina Emmanuel, Brainsight AI
• Digital Tools for Innovation in Biomedical Research and Education: Academia-Industry synergy in developing the Workforce of the Future, Jean-Philippe Laguerre, Dassault Systèmes & Natacha De Paola, Illinois Institute of Technology
• Harvi for Education, Mark Dickstein, MD, Columbia University Medical Center
• Strategy and Vision for the Future of the Virtual Human Twin Technology, Steven Levine, Dassault Systèmes

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