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6th Annual Living Heart Symposium Replay

Thank you for your interest, we hope you enjoy the videos. Be sure to download the Final Program that contains the biographies of each of the presenters.

Day 1 Plenary Session, Part 1

A look at the Dassault Systèmes journey toward the virtual twin experience of the human body followed by a Living Heart Project technical and community update and notable scientific studies in human modeling

  • Welcome and Opening Remarks - Steve Levine, Dassault Systèmes
  • A Journey Towards the Virtual Twin Experience of the Human Body - Claire Biot & Patrick Johnson, Dassault Systèmes 
  • The Living Heart Project - Steven Levine, Dassault Systèmes
  • Scientific Breakthroughs in Human Modeling:
    • Living Heart:  Mathias Peirlinck, Stanford University

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Day 1 Plenary Session, Part 2

Notable scientific studies in human modeling

  • Scientific Breakthroughs in Human Modeling:
    • Living Lung: Daniel Hurtado, Pontificia Universidad Católica de Chile, Mona Eskandari, University of California Riverside 
    • Living Brain: Nicolas Gazeres, Dassault Systèmes

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Student Showcase

Brief overviews of student research, offering a glimpse into the future of healthcare, hosted by Suyog Bhosale, Dassault Systèmes  

  • Effects of Dispersed Myofibre Architecture on Ventricular Pump Function, Debao Guan, University of Glasgow
  • Virtual Human Modelling and Simulation to Investigate Genetic Heart Diseases,    Francesca Margara, University of Oxford
  • Investigating the Soft-tissue Socket Interaction During Gait using FEA, Theodoros Marinopoulos, Loughborough University
  • FE Study of Heterotopic Ossification Formation on a Cervical Spine with Artificial Disc, Srikanth Srinivasan, Dilip Kumar S, Shruthi Ramachandran, S K Pugazhenthi, Deepak S, Senthil Kumar M, Balaji H, Vellore Institute of Technology- Chennai
  • Biomechanical Simulations of Resuscitation, Gunda Sachin, Indian Institute of Technology (IIT) Hyderabad

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Overview and Status Update on the FDA In silico Clinical Trial Project, Brent Craven, US Food and Drug Administration & Steven Levine, Dassault Systèmes

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Pursuits of Excellence - Accelerating Use of in Silico Clinical Trials

LH Symposium Breakout:  Accelerating the Use of in Silico Clinical Trials, hosted by Najib Abboud, Thornton Tomasetti  

  • Industry Perspectives on the Use of Computational Modeling & Simulation, Randy Scheistl, Boston Scientific
  • The Harvi Cardiovascular Simulation: Exploration of Surrogate Endpoints for an In silico Trial of MR Therapy, Daniel Burkhoff MD, Cardiovascular Research Foundation
  • What Slows the Adoption of In-silico Clinical Trials? (Panel) Najib Abboud, Thornton Tomasetti (Moderator); Randy Scheistl, Boston Scientific;  Daniel Burkhoff MD, Cardiovascular Research Foundation;  Alison Marsden, Stanford University; Dorothy Abel, Syntactx; Ashley Peterson, Thornton Tomasetti, Partho Sengupta, West Virginia University

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Pursuits of Excellence - Building Patient-Specific Models

LH Symposium Breakout:  Building Patient-Specific Models, hosted by Tom Battisti, Dassault Systèmes

  • Leveraging Machine Learning-based AI to Quickly Build Patient-Specific Living Heart Models, Kerim Genc, Synopsys  &  Paul Segars, Duke University
  • Pediatric Heart Modeling in a Clinical Environment, Noah Schulz, Boston Children’s Hospital
  • Patient/Population-Based Anatomical Modeling and Simulation, Ryan Benyshek  &  Ashley Stroh, Dassault Systèmes
  • Patient-Specific Simulation Parameter Tuning, Jiang Yao, Dassault Systèmes

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Pursuits of Excellence - Case Studies & Benefits of HPC on Cloud

LH Symposium Breakout:  Case Studies and Benefits of High-Performance Computing for Human Simulations In The Cloud, Hosted by Wolfgang Gentzsch, The UberCloud

  • High-performance Cloud computing for human simulations, digital twins, big data analytics, and AI,  Wolfgang Gentzch, The UberCloud
  • Multi-scale Modeling of Drug-induced Arrhythmias, Francisco Sahli, Pontificia Universidad Católica de Chile
  • Simulation of a Personalized Left Atrial Appendage Occluder Device with the Living Heart Model in the Cloud, Philipp Hempel, Admedes GmbH
  • Numerical Simulations in Cardiovascular Device Development and the Significance of Cloud Computing, Deepanshu Sodhani, Enmodes
  • HPC Cloud Simulation of Direct Current Brain Stimulation in Schizophrenia, Karl D’Souza, Dassault Systèmes 

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Pursuits of Excellence – Machine Learning & Other Reduced Order Models

LH Symposium Breakout:  Machine Learning and Other Reduced Order Models, hosted by Steve Levine, Dassault Systèmes

  • AI/ML in Life Sciences, Jing Bi, Dassault Systèmes
  • LHP Models to Train Machine Learning Model for Clinical Use, Julius Guccione, University of California San Francisco
  • Modelica Models for Cardiovascular System Modeling, Filip Ježek, University of Michigan

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Clinical Applications of Virtual Organs & Closing Remarks

Clinical Applications of Virtual Organs & Closing Remarks, hosted by Steve Levine, Dassault Systèmes

  • Utilization of 3D Models and Computational Simulations to Improve Operative Planning for Pediatric Cardiac Surgery, David Hoganson, MD, Boston Children’s Hospital
  • Patient-Specific Modeling of Heart Failure for COVID-19 Cases, Cristina Pop, MD & Alireza Heidari, McGill University
  • FE Solver Based Subject-specific Musculoskeletal Model for Analyzing Lower Extremity Biomechanics, Shihao Li, University of Tokyo

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Day 2 Plenary Session

Day 1 recap and goals for the day, followed up by the latest innovations in cardiovascular modeling and simulation

  • Day 1 Recap & Day 2 Outlook, Steven Levine, Dassault Systèmes
  • Replicating and Validating In Vivo Conditions to Simulate Leadless Pacemaker Motion in a Virtual Porcine Heart, Kevin Sack, Medtronic
  • Left Ventricular Biomechanics in Aortic Stenosis: Application of the Living Heart Human Model, Yunjie Wang, Thornton Tomasetti
  • Precision Structural Heart Interventions, Matthieu De Beule, FEops
  • Living Human Heart Project Mitral Valve Fluid-Structure Interaction Simulation, Tomasz Luniewski, CAPVIDIA

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Building the Virtual Human Twin - Living Brain

LH Symposium Breakout:  Building the Human Twin - Living Brain, hosted by Steve Levine, Dassault Systèmes

  • Brain Virtual Twin Generation Workflow for Epilepsy Surgery, Louise Moreau, Benoit Sarthou & Antoine Guillemain, Dassault Systèmes
  • Discussion Steve Levine, Dassault Systèmes (moderator)

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Building the Virtual Human Twin - Living Heart

LH Symposium Breakout:  Building the Human Twin Session - Living Heart, hosted by Tom Battisti, Dassault Systèmes
Please note, this link directs to the LHP Members Community which is only open to current Members of the Living Heart Project.

  • Technology and Model Update, Tom Battisti, Jiang Yao & Ashley Stroh, Dassault Systèmes
  • Mitral Valve Special Interest Group, Steve Kreuzer, Exponent, Inc.
  • Project Checkup, Tom Battisti, Dassault Systèmes

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Building the Virtual Human Twin - Living Lung

LH Symposium Breakout:  Building the Human Twin Session - Living Lung, hosted by Stuart Wright, Dassault Systèmes

  • Current Pulmonary Modeling and Simulation Applications Daniel Hurtado, Pontificia Universidad Católica de Chile, Mona Eskandari, University of California Riverside, Quentin Rouanet, Dassault Systèmes
  • Discussion,  Stuart Wright, Dassault Systèmes (moderator)

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Application Showcase

Latest breakthroughs in virtual human simulations

  • Numerical Analysis of Healthy, Diseased, and Prosthetic Aortic Valve within the LHHM, Adi Morany, Tel Aviv University
  • A Multi-Physics Simulation Framework Using Four-Chamber Cardiac Models, Adarsh Krishnamurthy, Iowa State University
  • Improving Patient Outcomes with an AI-driven Automation for Scan-to-print, Andy Kalambi, Rize, Inc. Subject-Specific Computational Models of the Human Tricuspid Valve, Manuel Rausch & Mrudang Mathur, University of Texas, Austin

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Innovation Centers, Future Direction & Closing Remarks

An overview of the 3DExperience Lab and Workforce of the Future -  Dassault Systèmes approach to foster entrepreneurship and strengthen society´s future of creation

  • ViTrack™, the First Standalone Continuous Non-invasive Blood Pressure Monitor,  Mohan Thanikachalam, Dynocardia
  • Developing and Validating Personalized Digital Human Brain Models for Neuro-psychiatric Disorders, Laina Emmanuel, Brainsight AI
  • Digital Tools for Innovation in Biomedical Research and Education: Academia-Industry synergy in developing the Workforce of the Future, Jean-Philippe Laguerre, Dassault Systèmes & Natacha De Paola, Illinois Institute of Technology
  • Harvi for Education, Mark Dickstein, MD, Columbia University Medical Center
  • Strategy and Vision for the Future of the Virtual Human Twin Technology, Steven Levine, Dassault Systèmes

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